Current Issue : July - September Volume : 2017 Issue Number : 3 Articles : 5 Articles
Alginate-based composite sponges were developed as carriers to prolong the gastric\nretention time and controlled release of curcumin-loaded self-microemulsifying drug delivery systems\n(Cur-SMEDDS). Liquid Cur-SMEDDS was incorporated into a solution made up of a mixture of\npolymers and converted into a solid form by freeze-drying. The ratio of alginate as the main polymer,\nadsorbent (colloidal silicon dioxide), and additional polymersââ?¬â?sodium carboxymethyl cellulose\n(SCMC), hydroxypropyl methylcellulose (HPMC)ââ?¬â?was varied systematically to adjust the drug\nloading and entrapment efficiency, sponge buoyancy, and the release profile of Cur-SMEDDS. The\noptimum composite sponge was fabricated from a 4% alginate and 2% HPMC mixed solution.\nIt immediately floated on simulated gastric fluid (SGF, pH 1.2) and remained buoyant over an 8 h\nperiod. The formulation exhibited an emulsion droplet size of approximately 30 nm and provided\nsustained release of Cur-SMEDDS in SGF, reaching 71% within 8 h compared with only 10% release\nfrom curcumin powder. This study demonstrates the potential of alginate-based composite sponges\ncombined with self-microemulsifying formulations for gastroretention applications involving poorly\nsoluble compounds....
Resveratrol (RSV) is well known for its anti-oxidant and anti-aging properties. However,\nresveratrol is insoluble in water and has stability issues. Recently, efforts were placed to prepare\na resveratrol-based advanced anti-aging topical product but it contains harsh organic solvents\nand oils that could be harmful to the human body and the environment. Hence, we propose\nthe use of a multifunctional dendrimer to solve the solubility and stability issues of resveratrol.\nA dendrimer-resveratrol complex was prepared, optimized and tested for solubility enhancement,\nstability in solution and cream dosage forms. We have also developed a high performance liquid\nchromatography method to measure the resveratrol within the final product. PAMAM dendrimers\nincreased the solubility and stability of resveratrol in water and semisolid dosage forms. Therefore,\nthis product would be water based ââ?¬Ë?greenââ?¬â?¢ formulation devoid of harsh organic solvents and oils\nand can be safely applied to the skin. Additionally, we have shown that the dendrimer helped to\nincrease overall RSV loading and skin penetration of resveratrol. The dendrimer-RSV formulation\nwas successfully scaled up towards commercialization. Dendrimer with RSV has led to an innovation\nin anti-aging cream and solutions that could be commercially marketed. Dendrimer-RSV complex\ncould also be added to other product forms for additional purposes and applications....
The present study involves the formulation and evaluation of oro-dispersible films of amlodipine besylate. In this research work three film formulations F1, F2, F3 were prepared consisting of drug alone, drug with super-disintegrant cross carmellose sodium, solid dispersion of the drug in PEG 6000 respectively using HPMC and propylene glycol. The films were fabricated by solvent casting method using amlodipine besylate, an anti hypertensive drug, undergoes the hepatic degradation of about 30% with half life 30-50 hrs. Buccal route is an excellent alternative method systemic drug delivery that can overcome the hepatic first pass effect and improve the bioavailability and therapeutic efficacy. Four formulations of solid dispersions SD1 – SD4 were prepared using two different ratios of polymer and two different methods of preparation. The optimized formulation of solid dispersion of drug was used in the film formulation F3. The formulations were evaluated for various physicochemical parameters along with in-vitro drug release studies. The study concluded that formulation F3 was the best formulation which follows first order release kinetics with R2 value 0.976. Drug delivery through oro-dispersible films provides many advantages compared to conventional dosage forms. This route can be further recommended for future development....
Oral route is the most widely preferred route for the administration of the drug. The drug losartan used in the treatment of hypertension has been formulated in the form of floating tablets. Losartan is the first orally available angiotensin-receptor antagonist without agonist properties. Following oral administration, losartan is rapidly absorbed, reaching maximum concentrations 1-2 hours post-administration. After oral administration approximately 14% of a losartan dose is converted to the pharmacologically active E 3174 metabolite. E 3174 is 10- to 40-fold more potent than its parent compound and its estimated terminal half-life ranges from 6 to 9 hours, in order to increase the half life of the drug it has been formulated in the form of floating tablets. The losartan potassium floating tablets were prepared using different low density polymers (Bees Wax, HPMC K4M, HPMC K15M, Ethyl Cellulose, Micro Crystalline Cellulose) in various proportions for prolongation of gastric residence time and to improve the patience compliance. The losartan potassium floating tablets were prepared by melt granulation method using 23 factorial design by taking drug release and total floating time and floating lag time as dependent variables, with the help of design expert software version 10. The losartan floating tablets were evaluated for friability, thickness, hardness, weight variation test, drug content, swelling index and in-vitro release, floating properties. The drug excipients compatibility studies between the drug and the excipients were evaluated by FT-IR. All the batches showed compliance with pharmacopoeial standards. Formulation F6 containing HPMC k15M showed sustained drug release for 6h (91%) emerging as best formulation. Percentage swelling index studies reveals that increasing polymer concentration percentage swelling was also increased. An in-vitro buoyancy study reveals that all batches showed good in-vitro buoyancy. Hence different low density polymers such as HPMCK15M, HPMC K4M and bees wax and in various proportions can be used to prepare losartan potassium floating tablets for prolongation of gastric residence time with enhanced patience compliance....
The aim of the present investigation is to produce rapidly disintegrating laminar extrudates for\ndelivering ibuprofen in the mouth of paediatric patients. This laminar shape is particularly\nconvenient for drug delivering in the mouth and can be easily cut in cut in different sizes allowing\nfor a convenient adjustment of the drug dose depending on the age of the patient. Due to the fact\nthat in paediatric formulations, the selection of the excipients is always a challenging issue and the\nreduction of their amount is always highly desirable, in this study to select the most appropriate\ncomposition to achieve a rapid disintegration and simultaneously permit a high amount of\nibuprofen in the system, an experimental design for mixtures was employed and the disintegration\ntime in simulated saliva was used as experimental response. In addition, after solid state analyses to\ncheck possible insurgence of drug-excipients interactions, laminar extrudates were characterised in\nterms of mechanical properties and in vitro dissolution performances. Extrudates with the desired\nuniform laminar shape, constant thickness (2 mm) and a very high content of drug (82% wt) were\nproduced. These products exhibited a short disintegration time. The dose for a patient of 6-12 years\ncorresponded to a length of extrudate between 1-1.5 cm, perfectly compatible with a formulation\norodispersible thin laminar extrudate intended for a paediatric patient (Figure 1)....
Loading....